Vol. 7, Issue 2, Part B (2025)

Background: Coronary artery disease (CAD) is a complex condition driven by multiple pathophysiological processes, evolving over time and manifesting through both acute and chronic clinical spectra. In this study, left ventricular performance was assessed using three-dimensional transthoracic echocardiography (3D-TTE) six months after percutaneous coronary intervention (PCI) to the left anterior descending artery (LAD) in patients who presented with acute ST-segment elevation myocardial infarction (STEMI).
Methods: This prospective observational single-center study was done on 100 STEMI patients undergoing LAD revascularization using percutaneous transluminal coronary angioplasty (PTCA).
Results: The significant improvement in LV parameters estimated by the Simpson's biplane method shows the positive impact of LAD revascularization on systolic function and cardiac structure statistically significant improvement in EF (p=0.013). A highly significant enhancement in EF was observed, with a statistically significant elevation in the mean value (p<0.001). Statistically significant improvements were noticed in the apical long-axis (GLS-LAX (p=0.047), median GLS-A4C, (p=0.002), and GLS-A2C (p=0.006)) views. 
Conclusions: LAD revascularization was associated with a significant and reverse remodeling of the left-sided cardiac valves, while right-sided and diastolic parameters remained unchanged over the 6-month period. There were successful reverse cardiac remodeling and a significant recovery of systolic function following LAD revascularization. There was a significant and consistent improvement in Global Longitudinal Strain across all measured views following revascularization.