Vol. 7, Issue 2, Part B (2025)

Background: Statins exert pleiotropic effects as a prophylaxis against cardiovascular events and have also been shown to improve diastolic function. In this study, we aimed to analyse the effect of statin therapy on the diastolic functional index in patients with diastolic dysfunction.

Methods: A systematic meta-analysis was performed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines to identify randomised controlled trial studies on the comparison of statin and placebo therapies in patients with diastolic dysfunction from the PubMed and Google Scholar databases. We evaluated the quality of the studies using Grading of Recommendations, Assessment, Development, and Evaluations Assessment. We performed a random-effects inverse-variance weighted meta-analysis of the outcomes, including echocardiographic index, to evaluate diastolic dysfunction.

Results: Data from the selected studies were analysed using RevMan Web. Two studies (271 patients) were included in the final analysis. Among all studies, the treatment and control groups showed no significant differences in the E/A ratio (mean difference [MD] = -0.10), isovolumic relaxation time (MD = -1.02), and E deceleration time (MD = -0.01). Overall, significant differences in left ventricular mass index (MD = -8.99), E velocity (MD = 1.16), and A velocity (MD = -0.68) were found between the groups.

Conclusion: Several significant changes in diastolic index are observed in patients with diastolic dysfunction who receive statin therapy. Further studies are required to evaluate the effects of statins on improving diastolic function in patients with diastolic dysfunction.