Vol. 6, Issue 1, Part A (2024)

Background: The C-reactive protein (CRP) to albumin ratio (CAR) is considered to provide a more precise measure of inflammatory state compared to CRP or albumin separately. Additionally, CAR has been linked to a less favorable outcome for individuals with critical conditions and malignancies. The purpose of the research was to correlate the CRP to CAR with the extent of coronary artery disease (CAD) in non-ST segment elevation myocardial infarction (NSTSEMI) patients.
Methods: The current work was carried out on 100 individuals aged from 40 to 68 years old, both sexes, with clinical criteria of NSTSEMI. Resting 12 electrocardiogram (ECG) leads, transthoracic echocardiography (echo), diagnostic coronary angiography and SYNTAX score (SS) calculation were assessed in all patients.
Results: The cut off value of >24.39 × 100 CAR yielded a sensitivity of 40.82%, a specificity of 96.08%, a positive predictive value (PPV) of 67.5% and a negative predictive value (NPV) of 63.3% in prediction of intermediate-high SS (>22) with AUC of 0.708 and P = <0.001. Normal ECG and ejection fraction (EF) were substantially greater in low SS group contrasted to intermediate-high SS group, but ST depression, inverted T, regional wall motion abnormalities, left main, left circumflex and right coronary arteries had been significantly decreased in low SS group contrasted to intermediate-high SS group (p<0.05).
Conclusion: Increased CAR was shown to be directly linked to the degree, intensity, and intricacy of coronary atherosclerosis as measured by the SS. CAR may serve as a biomarker to assess the magnitude and complexities of CAD in individuals with NSTEMI.